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Cagrilintide is an amylin receptor agonist, which operates through a different pathway than any of the three receptors retatrutide targets

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One hypothesis is that GIP enhances energy expenditure through effects on brown adipose tissue and skeletal muscle metabolism

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Indeed, cluster MES-2 shares 17% of marker genes with MES-1, and 37% of genes with the cluster of mature myocytes (MYO-2, described below), providing additional support to the idea that there are cells with dual identities in both MES-2

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