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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

10.1073/pnas.0402435101 14 BrunsN.LrcherS.MakyaK.PollardaJ.RenggliK.SpulberM

Clinical trials have shown that TRT can improve muscle mass, bone density, and energy in men with low testosterone (17)

For example, viral infections may dramatically increase the mortality rate in mammalian populations (e.g., border disease virus 6

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