Some of them have heavy metals
It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesnt necessarily mean that if you tolerate methylfolate well youll also need, want or tolerate methylcobalamin well (even if thats what most doctors, nutritionists, etc
Sipping water throughout the day rather than drinking large amounts at once tends to be more effective
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A single peptide addresses one or two aspects of a complex goal