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Given the initial improvement, we gradually stopped insulin therapy and increased metformin dose to 2 g per day, together with a hypocaloric diet after consultations with dietitians and 10 hours per week of physical activity
It's worth noting that the gastric emptying effect tends to attenuate over time with continued treatment
Diabetes Care 36 , 34603468 (2013)
Most patients experience identical outcomes on either formulation
If you have switched between medications, see our switching guide for managing side effects during transitions
[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Qian BB, Chen Q, Li L, Yan CF (2020) Association between combined treatment with SGLT2 inhibitors and metformin for type 2 diabetes mellitus on fracture risk: a meta-analysis of randomized controlled trials
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