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Reported MOTS-c side effects Side effect Injection site redness or swelling Frequency reported Common What to do Rotate sites, inject slowly

The most common side effects are nausea, diarrhea, constipation, and headache

Safety outcomes (adverse events) were synthesized descriptively because AE reporting was incomplete and not sufficiently consistent across trials to support quantitative synthesis

MD Patrick Tyrance, Jr

Figure 4 Discussion Structural analyses of the ghrelin receptor, enabled by advancements in structural biology techniques such as X-ray crystallography and cryo-EM, have provided detailed insights into the molecular mechanisms underlying the recognition of active ghrelin by its receptor

Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, and Shaper AG (1995)