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IGF-1 peptides are not approved for human use, and their safety has not been established in long-term clinical trials

One supplement (SNDS #276224, filed June 16, 2023) resulted in a Notice of Compliance issued November 1, 2023, with modifications to the Warnings and Precautions and Adverse Reactions sections of the product monograph [Source: dhpp.hpfb-dgpsa.ca/review-documents/resource/SBD00629]

van Buul-Offers et al (1995) have shown that overexpression of IGF-2 in transgenic normal and pituitary deficient Snell dwarf mice causes increased growth of the thymus, suggesting a role for IGF-2 in thymic development by paracrine or autocrine mechanisms

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