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2022 The major difference between these agents lies in canagliflozin, which is less selective for SGLT2 over SGLT1 and is metabolized primarily in the liver (compared to kidneys), and sotagliflozin, which inhibits both SGLT1 and SGLT2

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Evidence classification indicated that one outcome was Class II (6%), three outcome was Class III (18%), five were Class IV (29%), and the rest were NS

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