A higher risk of deficiency is present in patients with malabsorptive syndrome and/or unusually low sun exposure, those who have undergone gastric bypass surgery, or those on prolonged glucocorticoid use (which alters intestinal absorption) ( Cancer patients may have a higher risk of deficiency due to causes of intestinal fat malabsorption (i.e., intestinal surgery, pancreatectomy, gastrectomy) or due to oncologic treatments, such as aromatase inhibitors
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The most significant action is the glucose-dependent enhancement of insulin secretion from pancreatic beta cells
guide is another useful read
If you're concerned about nutritional adequacy during weight loss, discuss with your GP or a registered dietitian whether monitoring iron levels (including ferritin) or supplementation might be appropriate, particularly if dietary intake is significantly restricted
Factors that may contribute to muscle loss during weight loss in general, or with Ozempic treatment include: Appetite loss Loss of interest in eating Calorie restriction Low protein intake Pre-existing low muscle mass Low physical activity History of yoyo dieting (weight cycling) Older age Frailty Type 2 diabetes Obesity occurring with type 2 diabetes or prediabetes may also be associated with lower muscle mass, and can lead to a more rapid decline in muscle mass in the older person
