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Similarly, patients who experience other symptoms or signs suggestive of decreased arterial flow, such as ischemic bowel syndrome or Raynaud's syndrome following the use of any 5-HT agonist are candidates for further evaluation (see WARNINGS)

Peptide degradation pathways Tirzepatide is a 39-amino-acid peptide with specific structural modifications that make it effective, including alpha-aminoisobutyric acid (Aib) substitutions at positions 2 and 13 (which protect against DPP-4 enzyme degradation in the body) and a C20 fatty diacid chain at position 20 (which enables albumin binding for a longer half-life)

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- Not FDA-approved as a drug but widely used in cosmetic & regenerative medicine