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In the phase III clinical developmental programs of the DPP-4 inhibitors, non-inferiority was demonstrated after 1 and 2 years for these substances compared to sulfonylureas with respect to the glycaemic parameters HbA1c as well as fasting- and post-prandial plasma glucose concentrations

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[55] Semaglutide counteracts this resistance by downregulating inhibitory proteins like SOCS3 and PTP1B

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