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These are designed to balance effectiveness with tolerability

GP Lead BMedSci, BMBS, MRCGP (2017) Dr

This is an evolutionary survival mechanism

This does not mean MT2 has 'stopped working'

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Teriparatide: the first anabolic bone peptide Teriparatide is a recombinant N-terminal peptide fragment consisting of the first 34 amino acids of human parathyroid hormone