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If they still will not dissolve, the lyophilized powder may have been compromised before reconstitution, and you should consider discarding the vial
Skin injury or friction : Cuts, burns, or repeated rubbing of the skin can sometimes trigger new patches in vulnerable individuals
Mol Genet Metab 109:20814
Calcium has also been known to have similar effects in some cases
Ethionamide is commonly used in longer regimens, especially when other drugs like bedaquiline, clofazimine, delamanid, or linezolid are not feasible