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Unfortunately, MTX can trigger apoptosis in healthy tissues, including the liver (Abbas et al., 2023b)

RK15283) and MDA (cat

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Elevated CHOP disrupts apoptotic homeostasis by downregulating anti-apoptotic proteins (e.g., Bcl-2) and upregulating pro-apoptotic proteins (e.g., Bim), while simultaneously impairing the adaptive UPR, collectively driving dopaminergic neuron apoptosis in PD (18)

This typically follows confirmed diagnosis of B12 deficiency through blood tests and clinical assessment

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