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Comparing Weight Loss Results The head-to-head SURMOUNT-5 study shows that the dual-hormone treatment approach helped in reducing 20% of body weight compared to the single-hormone treatment that led to 15% weight loss
The key findings provide the most reliable timeline for expected results: Week 4: Average weight loss of approximately 1 to 2% of body weight Week 12: Average weight loss of approximately 5 to 6% of body weight Week 20: Average weight loss of approximately 10% of body weight Week 40: Average weight loss of approximately 13 to 14% of body weight Week 68: Average weight loss of approximately 15 to 17% of body weight These are averages, meaning some participants lost more and some lost less
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Since tirzepatide typically produces greater weight loss (20-25% body weight versus 15-17% with semaglutide at weight loss doses), more tirzepatide users may experience telogen effluvium simply because they lost more weight faster
Potential concerns include appetite stimulation, which may counteract weight-loss goals, and ghrelin-mediated effects on cortisol and sleep