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Elevated ROS and OS are common features of inflammation (Lv et al., 2019), altering inflammatory phenotype in DCM, including increased expression of cell adhesion molecules, increased macrophage and leukocyte infiltration, and increased expression of inflammatory cytokines (Westermann et al., 2007

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8 - 11 Prior to the approval of mecasermin in Canada, there were no approved treatments for SPIGFD

it helps modulate it, preventing the over-the-top inflammation that causes much of the collateral damage and feelings of sickness

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders