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FIGURE 7 Previous studies have shown that deferoxamine (DFO) inhibits the growth of esophageal squamous cell carcinoma (ESCC) cells by activating the ERK pathway in a ROS-dependent manner (Supplementary Figure S3E), and treatment with 800 M CGA led to a significant increase in ROS accumulation in hepatocytes (Figures 7F,G)

KCs are considered to be the first immune cells to come into contact with intestinal or hepatic autoimmune reactive substances and are rich in the expression of TLRs (51)

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massiliensis were then extracted from quality-filtered reads by using blastn algorithm [38] ( e value 50% stenosis for at least one coronary vessel) were recruited as an independent cohort for validating the microbiome-based TMAO producer prediction model (the baseline characteristics of CVD validation cohort were described in Table S2)

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Deletion peptides occur in solid-phase peptide synthesis (SPPS) when an amino acid is not added or is lost during sequence extension