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10.1161/CIRCRESAHA.110.223545 43

doi: 10.1016/s1072-7515(00)00704-3 36 CaballeroAEAroraSSaouafRLimSCSmakowskiPParkJYet al

Transketolase activity was inhibited using 100 M oxythiamine (Sigma-Aldrich) for 48 h

Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request

Altogether, these compounds constitute a class of metabolically activated NO prodrugs with potential for therapeutic use in a range of diseases, particularly cancer [79]