After removing 2,716 duplicate records, 3,825 studies underwent title and abstract screening
Patients should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that delay gastric emptying further Stay well hydrated with small, frequent sips of water throughout the day Avoid lying down immediately after eating
[30] Vomiting Vomiting is also a fairly common side effect of GLP-1s
"Since there are no head-to-head trials comparing oral semaglutide for obesity to orforglipron, this indirect treatment comparison from the ORION study provides important information that can be used during the shared decision-making process." Additionally, OPTIC was an online patient preference study assessing key factors driving obesity treatment decisions conducted from October to November 2025
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There was some evidence for effect modification of BMI by sex (P interaction = 0.09)
