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NAD+ is involved in the function of longevity regulators known as sirtuins, which means healthy NAD+ levels may support a long lifespan

Managing risk factors like high blood pressure, diabetes and cholesterol can prevent further damage

B12 has been shown to protect the brain against dementia, a condition that is increasingly prevalent in older adults

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People get them for all sorts of reasons like enhancing facial complexions, reducing toxins load, or detoxing

In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate