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In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

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Our experience shows that even a single freeze-thaw cycle can be enough to significantly degrade a substantial portion of the peptide in a vial, rendering the entire batch unreliable for serious research