References Pollard, B., & Pomfrett, C
Studies in ovariectomized mice showed that estrogen replacement increased GLP-1 release from both intestinal L-cells and pancreatic alpha-cells
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Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine Note: the FDA considers body composition metrics to be safety endpoints which often results in underpowered secondary endpoints in Phase 3 registration trials
The problem is that natural GLP-1 breaks down within minutes
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