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8 Remaining Questions and Knowledge Gaps There is strong evidence that synovitis drives worse outcomes in osteoarthritis, contributing to more severe and persistent pain, heightened pain sensitization, faster structural deterioration, and an increased need for joint replacement

Body lice may lay eggs on the host hairs and clothing, but clothing is where the majority of eggs are usually secured

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Many patients have accidentally taken 10-fold overdoses

Conformation of the piperidine ring in linagliptin enhances binding affinity, whereas, in sitagliptin, piperidine moiety is missing