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Wischik et al

Conclusion Epitalon is a synthetic peptide that has generated interest for its potential effects on melatonin production, circadian rhythms, and other age-related biological processes

Duracin de la actividad biolgica: Pese a la corta vida media plasmtica, los efectos posteriores sobre la expresin de telomerasa y la regulacin pineal persisten sustancialmente ms tiempo (das a semanas) coherente con el papel del Epithalon como molcula de sealizacin que desencadena cambios transcripcionales de mayor duracin en lugar de una actividad dosis-respuesta directa

CD8 + cytotoxic T lymphocytes, reactive to TPO and Tg, promote glandular destruction, aided by increased ICAM-1 expression on follicular cells and elevated serum levels of VCAM-1 and TIMP-1

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