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A new drug application was reportedly submitted in late 2025, putting it closest to potential approval

It is one of a growing class of mitochondrial-derived peptides (MDPs) that act as retrograde signals from the mitochondrion to the rest of the cell

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Hollander PA, Levy P, Fineman MS, Maggs DG, Shen LZ, Strobel SA, Weyer C, Kolterman OG

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This medication is not suitable for people with glaucoma, hyperthyroidism, or a history of stroke, substance use disorder, or some types of psychiatric illness