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doi: 10.3748/wjg.v20.i25.8082 66

This dual mechanism distinguishes it from precursor supplementation in research terms

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Glutamate works not only as a point-to-point transmitter, but also through spill-over synaptic crosstalk between synapses in which summation of glutamate released from a neighboring synapse creates extrasynaptic signaling/volume transmission

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It is important to note that the findings discussed below come primarily from laboratory and preclinical research