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[Abstract]2022 Nov;43(11):2956-2966

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

To further prove the influence of intracellular GSH level on the cytotoxicity of NSBSO, we pre-treated 4T1 and B16 cells with GSH synthesis inhibitor to reduce the intracellular GSH level, and the results showed that the pretreatment of the inhibitors gradually reduced the intracellular GSH to a very low level after 24 h treatment (Additional file 1: Fig

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