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Pathology (2017) 49:8790

Mol Metab 54:101352 Tan HL et al (2024) Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake

Strategies that reduce GI side effects: Taking the weekly injection in the evening so peak nausea occurs during sleep Eating smaller, lower-fat meals during the titration period Avoiding high-fat, fried, or heavily seasoned foods which worsen nausea Maintaining consistent hydration to prevent compounding issues Women experience more nausea than men Clinical trial data shows that nausea and vomiting are reported at higher rates in women than men on semaglutide

Early symptom onset correlated with a more severe clinical course [32]

pharmaceutical-journal.com Wilding JPH, et al