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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

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(PubMed) Gempel K, Topaloglu H, Talim B, et al

MsrA catalyzes the reduction of the S-form of methionine sulfoxide

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