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Yes, I was convinced it was my thyroid was what was wrong with me, (my mother has underactive thyroid) but two years down the line of injections I'm starting to feel much better, not lost any weight mind you

Invert the vial and slowly pull the plunger back, drawing exactly 1ml of water into the syringe

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However, DIO mice switched from an obesity-promoting WD to an LD (regardless of treatment status) displayed several genera and phyla differences compared to obese and lean controls

Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade