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Biomaterial-based delivery systems (hydrogels) have been shown to be excellent carriers that enhance cell/drug localization, survival and therapeutic efficacy in organ injury repair

doi: 10.1186/s12964-024-01922-1

Importantly, sleep disorders and circadian misalignment have been shown to further disrupt gut microbiota composition, leading to altered microbial metabolite profiles (Lin et al., 2024), impaired antioxidant production, and increased generation of ROS

It means your body natural fat mobilization during a caloric deficit provides the substrate

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