The pituitary gland produces adrenocorticotropic hormone in reaction to the release of corticotrophin-releasing factor from the hypothalamus, triggered by external stressors like pro-inflammatory cytokines
The numbers below are from the published REDEFINE 1 and REDEFINE 2 papers and the Novo Nordisk FDA filing announcement
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This enzyme requires riboflavin in the form of flavin adenine dinucleotide (FAD) and reduces FAD to FADH 2 during the reaction
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