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Comparable age groupings are proposed in the Dietary Guidelines for Americans, though the recommended intake levels differ, beginning at 0.5 g in infancy, increasing to 2.4 g for adults, and rising modestly during pregnancy and lactation (2.6 g and 2.8 g, respectively

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A meta-analysis of initial research showed that GLP-1s reduced the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) by 14%, all-cause mortality by 12%, hospital admissions for heart failure by 11%, and the composite kidney outcome by 21%

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No sub-analysis of clinical response according to background methotrexate use is yet available