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Despite the pharmacokinetic limitations, irregular adsorption and fast catabolism, the l-dopa became the standard oral pharmaceutical therapy of PD in the last fifty years [7]

Cellular immunity plays a central role, with Th1 and Th17 T-helper cells, autoreactive T cells, and B lymphocytes infiltrating the gland, recruiting neutrophils, macrophages, plasma cells, and CD8 + cytotoxic T cells, leading to follicular epithelial destruction

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Meanwhile, focus on fresh, whole foods that are naturally low in histamines

Some anecdotal reports and preliminary long-term studies suggest that continuous treatment could help preserve positive behavioral changes, but definitive evidence is lacking

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