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7.9% among those who continued semaglutide plus lifestyle intervention)

They work through different mechanisms and can produce synergistic effects

Showell et al

Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes Predicts Poor Long-term Glycemic Control

There is some evidence that GLP-1s might decrease collagen and moisture levels in the skin, for example, by turning off adipose-derived stem cells which, would otherwise stimulate fibroblasts in the skin to produce collagen, elastin, and hyaluronic acid, Steven Dayan, MD, a board-certified plastic surgeon in Chicago who has researched the impact of GLP-1s on skin, has told Allure

Nearly everyone hits at least one plateau