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Chuong, V

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP1 trial extension

With 94% amino acid sequence homology to native GLP-1, semaglutide has three structural modifications that make it less susceptible to degradation by dipeptidyl peptidase-4 (DPP-4) enzymes and prolong its half-life to approximately 1 week [1, 3]

In addition, she said, a five-point MACE event occurred in 1.2% of the semaglutide group and 1.5% of the tirzepatide group (incidence rates, 16.7 per 1,000 patient-years vs

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