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The single-cycle adenovirus replicates its genome (including the encoded spike transgene) 10,000 times but does not produce infectious virions
Controlled human trials specifically evaluating AOD-9604 for joint pain and osteoarthritis are needed to establish the level of efficacy and optimal treatment protocols
[DOI] [PMC free article] [PubMed] [Google Scholar] 406
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e071725e071725, www.bmj.com/content/383/bmj-2022-071725, Dangour, Alan D, et al
What exists is a growing body of preclinical data, early-phase human research, and a developing clinical consensus among peptide-prescribing physicians that points toward a relatively narrow therapeutic window
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