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A main focus of the loss-of-inhibition hypothesis in tinnitus is the role of \(\gamma \)-amino butyric acid (GABA), an inhibitory neurotransmitter, which, among others, is responsible for maintaining the balance between excitation and inhibition

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Therefore, the greater reduction in escape latency among younger animals could be due to their inherently higher baseline synaptic plasticity and neuronal signaling pathways, which are more amenable to enhancement by 1-MX

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doi: 10.1016/0378-8741(86)90165-0