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By alleviating lipotoxicity and inflammatory signaling, dual GLP-1 receptor agonists disrupt the feed-forward cycle driving hepatic fibrosis, thus offering a therapeutic avenue to prevent or reverse liver fibrosis in MASLD (40, 48)

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Finally, to address potential pleiotropic effects, we excluded SNPs associated with other potential confounders identified through PhenoScanner ( Outcome sources To minimize potential bias due to population diversity, we restricted our drug target MR analysis to participants of European ancestry

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2026 Mar:122:104954

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