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For example, 200300 mg/d of selenite supplementation, selenium-enriched yeast or high dietary selenium intake did not have a positive effect on sperm characteristics or activity, in spite of increased semen selenium concentrations (Reference Mistry, Pipkin and Redman66)

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172 Genes involved in pathways related to oxidative stress and antioxidant defense might therefore be potential genetic modifiers in AATD-related liver diseases, and warrant further investigation