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Thus, future therapeutic strategies should prioritize contexts where tumors exhibit non-oncogene addiction to CoQ 10 -dependent defense and should leverage delivery strategies and dosing regimens that maximize tumor exposure while minimizing systemic liabilities

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Renin-angiotensin system (RAS) inhibitors and nonsteroidal MRA are beneficial for treatment of CKD but may not fully block harmful effects of aldosterone

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According to Michels, this is one of the more severe signs of a vitamin C deficiency

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