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Therefore, the causal inferences drawn in this review should be interpreted with caution, acknowledging that the efficacy observed may be partially influenced by these methodological gaps

Given cryo-EM structures of the GLP-1R in complex with G s are stabilised by trapping the nucleotide-free G protein on the ligand-activated receptor, it is not surprising that the G s interactions are similar across the four structures, even when bound by different agonists, nonetheless the MD simulations revealed potential differences in the dynamics of these interactions

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[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Johnston J.B., Israels L.G., Goldenberg G.J., Anhalt C.D., Verburg L., Mowat M.R., Begleiter A