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Unsupervised clustering studies suggest identifiable endotypes with distinct reproductive and metabolic characteristics, such as the differentiation between reproductive-dominant and metabolic-dominant subtypes (51, 171, 172)

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Cycling strategies offer viable alternative to continuous use for many users, with protocols like 6 months on followed by 2-3 months off potentially maintaining 60-80% of continuous use benefits at 65-75% of annual cost while avoiding indefinite dependency and accommodation life flexibility

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