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Its precise copper chelation allows researchers to dissect copper-dependent enzymatic pathways with minimal off-target activity

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The potential role of adjunctive bone-protective therapies - including calcium and vitamin D supplementation, weight-bearing exercise, and, in selected high-risk cases, pharmacologic agents such as bisphosphonates - should be considered on an individual basis, though no evidence specifically addresses this question in MC4R -deficient patients

IC 50 20.43 M), PBMC (86%