Compounded medications occupy a gray zone in insurance coverage
Oral semaglutide, which is used for metabolic health and weight management, must be taken on an empty stomach with a small amount of water, followed by a 30-minute wait before eating or drinking anything else
Other potential risks include gallbladder problems (including gallstones), kidney problems (particularly in patients with existing kidney disease who become dehydrated), and hypoglycemia when combined with other diabetes medications
The studys limitations include a predominantly White population from the United States (US), a trial duration of one year, rescue therapy after week 24 that limited pure placebo comparisons, and the lack of continued treatment with injectables as a comparator
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Nat Rev Drug Discov 24 , 631650 (2025)