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Thus, we further explored whether GLP-1R is involved in CM by mediating microglial activation, including morphological changes and inflammation

Preliminary program results are promising: ~1,500 clients have enrolled in the program since the program launched in April 2023, including: 61% of commercial employer-sponsored lives 17% of commercial health plan lives ** 67% of members meet smart logic criteria and do not require submission of a PA request 84% of PA requests result in denial, and 72% overall target fill rate *** ~$1B or ~$4.86 PMPM in client savings 3 These drugs are being studied in both weight- and non-weight-related conditions

80 This trial was started in June 2020, with an expected read-out in 2024

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