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contraindications include pregnancy, breastfeeding, certain kidney or liver conditions, and some medications

Lancet 376 , 419430 (2010)

Stabilization of poliovirus by capsid-binding antiviral drugs is due to entropic effects

Two different DHAR isoforms have been discovered in Spinacia oleracea leaves with one isoform located in chloroplasts whereas the other being present in the sub-cellular compartment other than chloroplasts (Shimaoka et al., 2000)