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260 GLP-1 downregulated Na+/H+ exchanger isoform 3 in the renal proximal tubule of rats, suggesting that GLP-1 could be used to treat hypertension and sodium retention disorders

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A pilot study investigating the metabolic impact of intensive lifestyle intervention has shown that an intensive lifestyle programme consisting of structured educational group sessions and individual appointments can achieve sustained lifestyle improvement and weight loss in people with new onset of T2D without the need for oral glucose-lowering treatments [89]