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The restoration of spatial learning in APP/PS1 transgenic mice, which develop amyloid plaques and cognitive deficits analogous to human Alzheimer pathology, suggests that massive synaptogenic stimulation can override the connectivity losses caused by amyloid accumulation

1 A systematic review by the Endocrinology and Nutrition Unit, University of Pavia, concluded that Berberine positively influences gut microbiota and cholesterol absorption at doses around 300-500 mg/day, supporting its role as an adjunct in obesity and diabetes care

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Cancer 119(23):4083-5, 2013

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Phentermine is a central nervous system stimulant CNS just like amphetamines