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Through neural pathways as well as via receptor-mediated effects, GLP-1 reduces postprandial hyperglycemia by stimulation of insulin secretion, suppression of glucagon release, inhibition of gastric emptying and small intestinal peristalsis, and induction of satiety which limits meal size [17]

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JMs background metformin was continued As stressed in the ADA Standards of Care, metformin remains the recommended first-line pharmacologic therapy in patients with T2D and should be continued with the addition of other glucose-lowering therapies in those who can tolerate and do not have a contraindication to metformin therapy

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