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On the other hand, chronic GLP-1 activity in -cells increases its own secretion, feeding an autocrine loop that gets overstimulated with the use of exogenous synthetic GLP-1R agonists [(98)

The body produces less GLP-1, and the remaining GLP-1 is rapidly degraded by the enzyme DPP-4

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Mice that were treated with GLP-1MK-801 for 8 days displayed improved insulin sensitivity as assessed by an insulin tolerance test compared with mice that were treated with either monotherapy or vehicle (Fig

PMID: 16529340 DOI: 10.1331/154434506775268698 Tushuizen ME et al (2006): Incretin mimetics as a novel therapeutic option for hepatic steatosis

3B and 3 C for bioavailable testosterone, Figs